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Naturally occurring diallyldihydroxybiphenyl compounds, magnolol and honokiol were reported to have potent antibacterial activities against most of Gram positive bacteria (1-4). To develop more potent antibacterial agents, some allylhydroxybiphenyl derivatives were synthesized from the starting compounds, o-phenyl-phenol (I), p-phenylphenol (IV), o,o’’-biphenol (VII) and p,p’’-biphenol (XII). Among the newly synthesized compounds (III, VI, IX, XI, XIV and XVI), the antibacterial activities of 2-allyl-p-phenylphenol (VI), 6-allyl o,o’’-biphenol (IX), 2,2’’-diallyl-o,o’’-biphenol (XIV) and 2,2’’,6 triallyl-p,p’’-biphenol (XVI) were more potent than those of magnolol and honokiol against a cariogenic bacterium, Streptococcus mutans ATCC OMZ176.
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